LONDON--(EON: Enhanced Online News)--Technavio’s latest report on the global chemotherapy-induced nausea and vomiting (CINV) drugs market provides an analysis of the most important trends expected to impact the market outlook from 2017-2021. Technavio defines an emerging trend as a factor that has the potential to significantly impact the market and contribute to its growth or decline.
“The high unmet medical need in the market is driving the vendors and research organizations to conduct extensive R&D activities, which is expected to bring novel drugs for the treatment of CINV. Currently, the market is characterized by the presence of serotonin receptor antagonists and NK1 receptor antagonists.”
Sapna Jha, a lead analyst from Technavio, specializing in research on central nervous system sector, says, “The high unmet medical need in the market is driving the vendors and research organizations to conduct extensive R&D activities, which is expected to bring novel drugs for the treatment of CINV. Currently, the market is characterized by the presence of serotonin receptor antagonists and NK1 receptor antagonists.”
For instance, Helsinn is one of the leading vendors in the market with flagship drug, Aloxi, which reported revenue of approximately USD 563 million in 2015. The increased need for effective treatments has driven Helsinn to conduct extensive R&D activities and subsequently launched Akynzeo, a fixed-dose combination of palonosetron and netupitant. The patent exclusivity till 2019 will enable Helsinn to generate substantial revenue during the initial phase of the forecast period.
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The top three emerging trends driving the global CINV drugs market according to Technavio healthcare and life sciences research analysts are:
- Robust R&D activities fueling the pipeline
- Increasing inorganic growth strategies likely to fuel the market growth
- Novel treatment options coupled with new applications
Robust R&D activities fueling the pipeline
The high unmet medical need in the market has driven the R&D activities of existing as well as new vendors. Helsinn is one of the leading companies that has a strong pipeline of CINV drugs with two drug candidates in Phase III and Phase I stages. Helsinn has collaborated with Taiho Pharmaceutical for the development and commercialization of netupitant IV in Japan. Heron Therapeutics is developing HTX-019, currently in Phase I stage, for the prevention and treatment of CINV.
“New vendors such as Shin Nippon Biomedical Laboratories and Acacia Pharma are aggressively advancing their pipeline to launch new drugs during the forecast period. Shin Nippon Biomedical Laboratories and Acacia are developing granisetron intranasal and APD403, respectively,” according to Sapna.
Increasing inorganic growth strategies likely to fuel the market growth
The vendors are looking to expand their product portfolio and market presence by pursuing inorganic growth strategies such as acquisitions and alliances. These strategies allow the companies to reduce R&D costs and quickly penetrate into the market. For instance, in April 2016, Helsinn and Purdue Pharma Canada entered an exclusive agreement for the distribution and licensing of Akynzeo.
Under the terms of the agreement, Helsinn retains clinical development activities and the manufacturing and commercialization of Akynzeo, a drug used for the prevention of CINV, while Purdue Pharma Canada will have exclusive rights for the registration, promotion, and commercialization of Akynzeo in Canada.
Novel treatment options coupled with new applications
The focus of vendors toward the development of novel treatment options will likely change the market dynamics. Currently, the vendors are focusing on developing drugs that improve patient compliance significantly. This has driven the launch of oral therapies in the market, which are expected to witness an increased adoption in the coming years. For instance, in August 2016, BioStem Technologies acquired its first US FDA-approved branded generic drug, Granisol Oral Solution, for preventing nausea and vomiting linked with cancer chemotherapy and radiation treatments.
Moreover, the expansion of CINV drugs into new applications such as pediatric use is expected to have a positive impact on the market growth. As some of the cancers such as leukemia are most prevalent in children (accounts for 30% of all cancers in children), the approval of drugs in this application will help to address the untapped market.
The key vendors are as follows:
- Heron Therapeutics
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Technavio analysts employ primary as well as secondary research techniques to ascertain the size and vendor landscape in a range of markets. Analysts obtain information using a combination of bottom-up and top-down approaches, besides using in-house market modeling tools and proprietary databases. They corroborate this data with the data obtained from various market participants and stakeholders across the value chain, including vendors, service providers, distributors, re-sellers, and end-users.
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